Immunologic changes underlying to an egg OIT protocol in a pediatric population

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Immunologic changes underlying to an egg OIT protocol in a pediatric population

Background Egg allergy is one of the most common food allergies in childhood with an estimated prevalence of 2.6 %. Oral immunotherapy (OIT) appears as a promising approach to induce egg-tolerance. However, the immune mechanisms underlying this treatment are not completely known. The purpose of the study was to compare the immune responses against egg allergens of a pediatric population under a...

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Reduced Th1 and Treg immune responses in a pediatric egg-allergic group susceptible for an OIT protocol

Background Egg allergy is one of the most common food allergies of childhood with an estimated prevalence of 2.6 %. Allergic reactions to egg may vary from atopic dermatitis to systemic anaphylaxis. Although traditionally the only treatment is dietary avoidance, oral immunotherapy (OIT) appears as a promising approach to induce eggtolerance. However, the immune mechanisms underlying this treatm...

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Home-based oral immunotherapy (OIT) with an intermittent loading protocol in children unlikely to outgrow egg allergy

BACKGROUND Home based oral immunotherapy (OIT) for food allergy has often been used for young children in Japan, the majority of whom are believed to outgrow the allergy by the school age, therefore the true efficacy of the therapy has been controversial. The aim of this study was to evaluate the efficacy and safety of a newly developed slow- type home-based oral immunotherapy (OIT) regimen in ...

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Immunologic shifts occurring during cow milk (CM) oral immunotheray (OIT)

Methods Series of cases involving 15 children over 4 years and adolescents who still had anaphylaxis to cow’s milk. Specific IgE levels were evaluated in three steps of OIT: at baseline, pre-treatment session (step 1); When the patient reached the concentration 1:1 (step 2); and when reaching the final volume to 150 ml of milk a day (step 3). The differences between the levels of specific IgE w...

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A new OIT protocol for severe peanut allergy

Methods Our pirmary outcome was the increase in the amount of ingested peanut protein tolerated in DBPCFC by peanut OIT. Secondarily we investigated safety of OIT. Since September 2011, peanut-sensitized patients with moderate to severe allergic reaction (1) in DBPCFC were included. Bronchial hyperreactivity, exhaled nitric oxide, and food allergy related quality of life (2, 3) were evaluated p...

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ژورنال

عنوان ژورنال: Clinical and Translational Allergy

سال: 2015

ISSN: 2045-7022,2045-7022

DOI: 10.1186/2045-7022-5-s3-o15